Prognostic significance of the AML1-ETO fusion transcript expression in children and young adults with t(8;21) acute myeloid leukemia.
نویسندگان
چکیده
We performed serial nested reverse transcription polymerase chain reaction (RT-PCR) assays to monitor minimal residual disease (MRD) in 25 patients with t(8;21) acute myeloid leukemia (AML). We found transient disappearance of the AML1-ETO transcript in most of the patients in complete remission. Durable PCR-negativity was found in a subgroup of patients and was associated with a good prognosis.
منابع مشابه
Geographic Heterogeneity of the AML1-ETO Fusion Gene in Iranian Patients with Acute Myeloid Leukemia
Background: The human AML1 gene, located on chromosome 21, can be fused to the AML1- eight-twenty-one (ETO) oncoprotein on chromosome eight, resulting in a t(8;21)(q22;q22) translocation. Acute myeloid leukemia (AML) associated with this translocation is considered a distinct AML with a favorable prognosis. Due to the various incidences of the translocation, which is associated with geographic ...
متن کاملAML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.
A variety of genetic lesions, including chromosomal translocations, internal tandem duplications, and mutations, have been described in acute myeloid leukemia (AML). Expression profiling has shown that chromosomal translocations, in particular, are associated with distinctive patterns of gene expression. AML exhibiting the translocation t(8;21), which fuses the AML1 and ETO genes, has such a ch...
متن کاملDetection of the AML1/ETO Fusion Transcript in the t(8;21) Masked Translocation in Acute Myelogenous Leukemia I
The fusion transcript AML1/ETO was detected in the bone marrow of two t(8;21)-negative acute myelogenous leukemia (AML) patients by means of reverse transcription-polymerase chain reaction. This fusion transcript is identical to the one transcribed from the t(8;21) translocation base, as deduced from (a) the size and restriction pattern of the amplified DNA fragment and (b) the DNA sequence ana...
متن کاملDetection of the AML1/ETO fusion transcript in the t(8;21) masked translocation in acute myelogenous leukemia.
The fusion transcript AML1/ETO was detected in the bone marrow of two t(8;21)-negative acute myelogenous leukemia (AML) patients by means of reverse transcription-polymerase chain reaction. This fusion transcript is identical to the one transcribed from the t(8;21) translocation base, as deduced from (a) the size and restriction pattern of the amplified DNA fragment and (b) the DNA sequence ana...
متن کاملThe ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor.
The 8;21 translocation, t(8;21)(q22;q22.3), is seen only in acute myelogenous leukemia and is characteristically associated with the M2 subtype. Subsequent to our identification of the t(8;21) breakpoint region on chromosome 21, we reported that the translocation results in the fusion of the AML1 gene on chromosome 21 with a novel gene on chromosome 8 which we called ETO (for eight twenty-one)....
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ورودعنوان ژورنال:
- Haematologica
دوره 88 9 شماره
صفحات -
تاریخ انتشار 2003